Advancing Drug Discovery with Protein Degrader Screens

PROTAC® (PROteolysis TArgeting Chimeras) Degraders are small molecules that use the ubiquitin-proteasome system to selectively degrade target proteins within cells. To discover novel drugs, researchers use high-throughput platforms to screen large Degrader compound libraries. Scientists optimize their screens with an automated immunoassay platform that accurately quantifies degradation activity in less time and at a lower cost compared to traditional Western blots.

Download this application note from Protein Simple to learn how researchers utilize the Simple Western platform to design and optimize targeted protein degradation strategies.

PROTAC^® is a registered trademark of Arvinas Operations, Inc., and is used under license