Liquid chromatography (LC) – either as a standalone technique or coupled with mass spectrometry (LC-MS) – is widely used in a number of fields, ranging from forensic science to clinical diagnostics. Chromatographic performance is highly dependent on water purity, as water is a key solvent used in sample pretreatment and the preparation of eluents, reagent blanks, and standards. Low water purity affects calibration accuracy and the presence of organic compounds or bacteria in water can degrade samples. Finally, the particulate matter present in untreated water can clog the column, pump, and filters of an LC system, increasing maintenance burdens.
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